Introduction: Conservatism is a product of comfort. Only through breakthroughs and innovations can all sciences and technologies continue to progress. Breaking free from the shackles of traditional thinking and forging an innovative path for the future world—this is an era where opportunities and challenges coexist, and an era where the future is won through innovation. This is the development trend of the pharmaceutical industry, and even more, the responsibility and commitment of each and every one of us.

On June 11th, the 2022 15th TIANS Technology Forum (hereinafter referred to as the Forum), hosted by TIANS Engineering Technology Group Co., Ltd. and co-organized by Dandelion and the China Pharmaceutical Intelligent Manufacturing Industry Alliance, was grandly held online for the first time. With the theme of "Reconstruction and Rebirth: Discussing the New Ecology of Pharmaceuticals", this forum gathered the ecological forces of industry, academia, and research to help the pharmaceutical industry upgrade towards low-carbon and intelligent development. A total of 16,504 professional viewers watched online, seeking rebirth and gaining insights into the future together with industry experts.

This forum is hosted by Mr. Zhang Jinwei, founder of Dandelion and vice chairman of the TIANS Technology Forum Organizing Committee.

Zhang Jinwei, Host of TIANS Technology Forum

Mr. Wu Yafeng, Director, President and Chief Designer of TIANS Group, delivered the opening speech at the forum. Wu Yafeng stated that 2022 marks the 15th year that the TIANS Technology Forum has walked alongside industry colleagues, and it is also a crucial year for chemical and biological pharmaceutical enterprises to break through difficulties and achieve new growth. He hopes that numerous pharmaceutical enterprises can accelerate the in-depth integration of science and technology with production practice through the TIANS Technology Forum, and promote the transformation and upgrading of enterprises as well as the sustainable development of the industry.

Wu Yafeng, President of TIANS Group, delivered the opening speech

Experts' Discussion: Unlocking the Future Direction of Pharmaceuticals
This forum invited well-known industry experts, scholars from colleges and universities, and business leaders at home and abroad to conduct in-depth discussions on six hot industry topics: the "14th Five-Year Plan" for the pharmaceutical industry, unmanned environmental protection factories, micro-chemical engineering and continuous flow, international cutting-edge biopharmaceutical factory design concepts, bioreactors, and the implementation of informatization.

During the "13th Five-Year Plan" period, pharmaceutical innovation made rapid progress, the industrial concentration was further enhanced, and pharmaceutical exports achieved rapid growth. However, there were problems such as unbalanced development of various sub-industries, intensified differentiation in enterprise operations, and slow upgrading of the export structure. Mr. Wang Xuegong, Executive Vice President of the China Pharmaceutical Enterprise Management Association, delivered a keynote speech entitled "Analysis of the Development Situation of the Pharmaceutical Industry During the '14th Five-Year Plan' Period". Wang Xuegong stated that the "14th Five-Year Plan" period is a critical period for the adjustment of the pharmaceutical industry structure, a critical period for the transformation of innovation-driven development, and also a critical period for the establishment of new growth models and new industrial patterns. During this stage, various forces are in a state of entanglement and game, and the industry may usher in major changes in development. Wang Xuegong emphasized that during the "14th Five-Year Plan" period, the focus is to accelerate the transformation of innovation-driven development, build advantages in the industrial chain, improve manufacturing levels, improve the drug supply guarantee system, create international competitive advantages, and build a high-value, high-level, and internationalized large Chinese pharmaceutical market.

Wang Xuegong delivered a keynote speech titled "Analysis of the Development Situation of the Pharmaceutical Industry during the '14th Five-Year Plan' Period"

Dr. Chen Ping, Director, Vice President, and Chief Technology Officer of TIANS Group, delivered a keynote speech titled "Intelligent and Lean Operations of Sewage Treatment Workshops in Chemical Enterprises". He elaborated on five aspects: problems and countermeasures in environmental protection workshops, biodegradation of pollutants and case reviews, SND technology, intelligent control, and plans for energy conservation, consumption reduction, and emission reduction. Dr. Chen Ping stated that through intelligent control methods such as precise aeration, precise dosing (for phosphorus removal), precise Fenton sludge reduction, stable water inflow precise control, and precise control of hydrolysis acidification, the environmental protection workshops of pharmaceutical enterprises can achieve improvement in efficiency, significant reduction in costs, safer production, increasingly lean management, and more dynamic decision-making, ultimately realizing a green and intelligent future.

Chen Ping gave a keynote speech titled "Intelligent and Lean Management of Wastewater Treatment Workshops in Chemical Enterprises"

Professor Luo Guangsheng from Tsinghua University, who is also the director of the State Key Laboratory, delivered a keynote speech entitled "Microchemical Technology and Continuous Flow Synthesis". Professor Luo Guangsheng first introduced the urgent demand for new technologies, new equipment, and new processes in the field of chemistry and chemical engineering at the current stage, starting from the challenges faced by chemical production and chemical synthesis research. Subsequently, Professor Luo Guangsheng elaborated on microchemical technology, stating that this technology involves continuous, efficient, and controllable reaction and separation processes carried out in confined spaces of micrometer or submillimeter scale. It adheres to the basic principle of "numbering-up", directly applying laboratory achievements to industrial processes, thereby realizing the large-scale preparation of chemicals. For the pharmaceutical industry, how to achieve continuous production from batch production has been a hot research direction in recent years. In the second half of the lecture, he introduced the development direction of continuous chemical synthesis technology from the aspects of continuousization of batch processes and continuousization of complex multi-step reactions, providing strong theoretical support for the exploration of continuous production in the pharmaceutical industry.

Luo Guangsheng delivered a keynote speech on "Microchemical Technology and Continuous Flow Synthesis"

Mr. Christian Bachofen, Director of TIANS Group, Chief Technology Officer of Biomedicine, and internationally renowned expert in biomedical design and planning, presented content on international advanced layout concepts and added value of biopharmaceutical factories on the topic of "Basic Elements of Biological Factory Design". He pointed out that factory design should play roles such as reducing the risk of errors, ensuring the clean state of production areas, and guaranteeing good product quality. Combining with international advanced factory design examples, he put forward the concepts of bay and pressure difference, and elaborated on the layout settings of areas such as cell expansion area, cell culture area, quarantine area, downstream process area, as well as preparation area and filtration area, bringing forward-looking ideas and concepts to the majority of biopharmaceutical enterprises.

Christian Bachofen delivered a keynote speech titled "Sharing of International Cutting-edge Biopharmaceutical Factory Design Concepts"

Biomanufacturing is a green driving force for the transformation and upgrading of traditional industries, and also an important breakthrough for green development. At the forum, Professor Zhuang Yingping, Dean of the School of Bioengineering at East China University of Science and Technology, delivered a keynote speech titled "Bioreactors and Intelligent Biomanufacturing". She pointed out that the biomanufacturing industry is the focus of competition among countries around the world, and bioreactor engineering is the key to improving the level of biomanufacturing. She shared the latest research results of the State Key Laboratory of Bioreactor Engineering - optimization research technologies and applications based on the combination of process metabolic parameters and microscopic physiological parameters. She explained in detail five key technologies such as intelligent perception, intelligent analysis, and intelligent execution, along with practical cases, opening the door to future intelligent biomanufacturing with cutting-edge industry technologies.

Zhuang Yingping delivered a keynote speech on "Bioreactors and Intelligent Biomanufacturing"

Currently, information technology professionals in the pharmaceutical industry are facing unprecedented technical challenges. How to leverage the new generation of information technology to coordinate and advance the process of enterprise digital transformation is a common test for the industry. At the forum, Mr. Yang Yujie, Manager of the Engineering and Equipment Department of Beijing Sinovac Biotech Co., Ltd., gave an in-depth sharing on "How Information Systems Can Be Implemented in Biopharmaceutical Enterprises". He elaborated on specific aspects such as the enterprise information technology planning blueprint, implementation roadmap, and organizational structure, with a focus on explaining the construction of the MES system, which serves as a bridge connecting OT and IT. Finally, he demonstrated the achievements and value embodiment of production management, material management, quality management, and electronic record delivery in pharmaceutical enterprises after the implementation of information technology, providing a highly referential action guide for the information technology implementation of numerous biopharmaceutical enterprises.

Yang Yujie delivered a keynote speech titled "How Informatization Systems Can Be Implemented in Biopharmaceutical Enterprises"

Industry-University-Research Collaboration – Realizing Conceptions through Technology
The integration of industry, university, and research is not only the synergy and integration of resource advantages but also the connection and coupling of the upstream, midstream, and downstream of technological innovation. To better help the industry solve problems and take the path of high-quality development, two industry-university-research dialogue sessions are specially set up during this forum.